{"id":22,"date":"2021-01-13T21:47:32","date_gmt":"2021-01-13T20:47:32","guid":{"rendered":"https:\/\/www.ibd-comfort.cz\/?page_id=22"},"modified":"2021-01-28T23:53:51","modified_gmt":"2021-01-28T22:53:51","slug":"nove-minimalne-invazivni-moznosti-lecby-pooperacni-recidivy-crohnovy-choroby-na-experimentalnim-modelu","status":"publish","type":"page","link":"https:\/\/www.ibd-comfort.cz\/vyzkum\/nove-minimalne-invazivni-moznosti-lecby-pooperacni-recidivy-crohnovy-choroby-na-experimentalnim-modelu\/","title":{"rendered":"Nov\u00e9 minim\u00e1ln\u011b invazivn\u00ed mo\u017enosti l\u00e9\u010dby poopera\u010dn\u00ed recidivy Crohnovy choroby na experiment\u00e1ln\u00edm modelu"},"content":{"rendered":"\r\n<div class=\"block-slider alignfull\">\r\n\r\n    <div class=\"slider slider--fade ns shape-bottom alignfull\" data-slider='{ \"type\": \"fade\", \"speed\": 2500, \"autoplay\": false, \"interval\": 5000, \"lazyLoad\": \"nearby\", \"rewind\": true, \"arrows\": false, \"drag\": false, \"pagination\": false, \"waitForTransition\": false, \"breakpoints\": { \"959\": { \"pagination\": false } }  }'>\r\n        <div class=\"slider__track\">\r\n            <div class=\"slider__list\">\r\n\r\n            \r\n                <div class=\"slider__slide block-slide\">\r\n\r\n                    <div class=\"block-slider-wrapper\" style=\"background: linear-gradient(90deg, rgba(76,76,76,1) 30%, rgb(76,76,76) 50%, rgba(76,76,76,1) 80%)\">\r\n\r\n                        \r\n                                                <div class=\"block-slider-content flex middle-xs parallax\">\r\n                            <div class=\"align\">\r\n\r\n                                <div >\r\n\r\n                                    \r\n                                                                            <h1 class=\"block-slider-title slider-title has-white-text-color\">Nov\u00e9 minim\u00e1ln\u011b invazivn\u00ed mo\u017enosti l\u00e9\u010dby poopera\u010dn\u00ed recidivy <br><span>Crohnovy choroby na experiment\u00e1ln\u00edm modelu<\/span><\/h1>\r\n                                                                                                                \r\n                                    \r\n                                    \r\n                                    \r\n                                <\/div>\r\n\r\n                            <\/div>\r\n                        <\/div>\r\n\r\n                        \r\n                        <div class=\"block-slider-back opacitor parallax-opposite blurry\">\r\n\r\n                            <span class=\"block-slider-back-left\" style=\"background: rgb(76,76,76);\"><\/span>\r\n                            <span class=\"block-slider-back-right\" style=\"background: rgb(76,76,76);\"><\/span>\r\n                            <div class=\"block-slider-back-anim\">\r\n                                                                <span class=\"block-slider-back-anim-radial\" style=\"background: 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mo\u017enosti l\u00e9\u010dby poopera\u010dn\u00ed recidivy  Crohnovy choroby na experiment\u00e1ln\u00edm modelu\" loading=\"eager\">\r\n                                <\/noscript>\r\n\r\n                                                            <\/div>\r\n                        <\/div>\r\n\r\n                    <\/div>\r\n                <\/div>\r\n\r\n            \r\n            <\/div>\r\n        <\/div>\r\n\r\n        <svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" preserveAspectRatio=\"none\" viewBox=\"0 0 1675 105\">\r\n            <g transform=\"translate(837.5,52.5) scale(1,-1) translate(-837.5,-52.5)\"><path fill=\"#fff\" opacity=\"0.59\">\r\n              <animate attributeName=\"d\" dur=\"7.142857142857142s\" repeatCount=\"indefinite\" keyTimes=\"0;0.333;0.667;1\" calcmod=\"spline\" keySplines=\"0.2 0 0.2 1;0.2 0 0.2 1;0.2 0 0.2 1\" begin=\"0s\" values=\"M0 0L 0 70.27869300384415Q 279.1666666666667 56.83666822674619  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civiliza\u010dn\u00ed, imunitn\u011b podm\u00edn\u011bn\u00e1 onemocn\u011bn\u00ed. Systematick\u00fd p\u0159ehled literatury za posledn\u00edch 60 let potvrzuje rychle rostouc\u00ed incidenci onemocn\u011bn\u00ed zejm\u00e9na v&nbsp;pr\u016fmyslov\u011b vysp\u011bl\u00fdch zem\u00edch, dosahuj\u00edc\u00ed podle posledn\u00edch v\u00fdsledk\u016f 24,3 nov\u011b diagnostikovan\u00fdch pacient\u016f s&nbsp;UC a 12,7 s&nbsp;CD na 100&nbsp;000 osob v&nbsp;Evrop\u011b za rok a zdvojn\u00e1sobuje se ka\u017ed\u00fdch 10 let. Z\u00e1kladn\u00ed i klinick\u00fd v\u00fdzkum v&nbsp;oblasti etiologie a patogeneze t\u011bchto onemocn\u011bn\u00ed, stejn\u011b jako hled\u00e1n\u00ed nov\u00fdch mo\u017enost\u00ed medikament\u00f3zn\u00ed, endoskopick\u00e9 a chirurgick\u00e9 l\u00e9\u010dby, nab\u00fdvaj\u00ed v&nbsp;oboru gastroenterologie na mimo\u0159\u00e1dn\u00e9 d\u016fle\u017eitosti.&nbsp;<\/p>\n\n\n\n<p>P\u0159es pokroky v&nbsp;medikament\u00f3zn\u00ed terapii jsou pacienti&nbsp; s&nbsp;Crohnovu chorobou&nbsp; a\u017e v&nbsp;75% p\u0159\u00edpad\u016f v&nbsp;pr\u016fb\u011bhu \u017eivota operov\u00e1ni, p\u0159i\u010dem\u017e a\u017e 50% z&nbsp;nich mus\u00ed z\u00e1krok podstoupit v&nbsp;prvn\u00edch 10 letech onemocn\u011bn\u00ed. Nej\u010dast\u011bj\u0161\u00edm typem opera\u010dn\u00edho v\u00fdkonu je ileo-c\u00e9k\u00e1ln\u00ed resekce. U 70% z&nbsp;t\u011bchto nemocn\u00fdch, kte\u0159\u00ed ji\u017e podstoupili jeden chirurgick\u00fd v\u00fdkon, dojde do 1 roku k&nbsp;rekurenci onemocn\u011bn\u00ed v&nbsp;m\u00edst\u011b anastom\u00f3zy. \u0158ada z&nbsp;nich pak mus\u00ed b\u00fdt opakovan\u011b operov\u00e1na. Nej\u010dast\u011bj\u0161\u00edm d\u016fvodem pro re-operace u Crohnovy choroby je vznik v\u00fdznamn\u00e9 (t\u011bsn\u00e9) sten\u00f3zy ve vytvo\u0159en\u00e9 ileo-kolick\u00e9 anastom\u00f3ze. Jednou z&nbsp;ne-chirurgick\u00fdch metod jak vy\u0159e\u0161it sten\u00f3zy u st\u0159evn\u00edch anastom\u00f3z a vyhnout se tak nutnosti dal\u0161\u00ed chirurgick\u00e9 intervence, je endoskopick\u00e1 balonov\u00e1 dilatace pomoc\u00ed TTS (Trough-the-scope) balon\u016f. V&nbsp;pr\u016fb\u011bhu endoskopick\u00e9ho z\u00e1kroku je do krat\u0161\u00ed (cca do 50 mm d\u00e9lky) a nekomplikovan\u00e9 sten\u00f3zy (bez p\u0159\u00edtomnosti hlubok\u00fdch v\u0159ed\u016f, esovit\u00e9 deformace \u010di nep\u0159\u00edtomn\u00e9 p\u00ed\u0161t\u011ble) zaveden postupn\u011b rozepnut\u00fd balon a tlakem 1.5-3 atmosf\u00e9ry je sten\u00f3za roz\u0161\u00ed\u0159ena na pr\u016fm\u011br cca 18mm. I kdy\u017e je tato metoda relativn\u011b velmi efektivn\u00ed a to zvl\u00e1\u0161t\u011b u \u201eblanit\u00fdch\u201c a kr\u00e1tk\u00fdch sten\u00f3z, p\u0159esto u 40-60% pacient\u016f tato l\u00e9\u010dba selh\u00e1v\u00e1, nebo je efekt jen p\u0159echodn\u00fd na n\u011bkolik m\u011bs\u00edc\u016f. D\u016fsledkem je pak nutnost opakovan\u00e9ho prov\u00e1d\u011bn\u00ed dilatac\u00ed nebo dokonce dal\u0161\u00ed chirurgick\u00e1 intervence spo\u010d\u00edvaj\u00edc\u00ed v&nbsp;resekci posti\u017een\u00e9ho \u00faseku st\u0159eva.<\/p>\n\n\n\n<figure class=\"lazyload block-image alignwide size-large\"><img loading=\"lazy\" decoding=\"async\" width=\"1600\" height=\"1200\" src=\"https:\/\/www.ibd-comfort.cz\/content\/uploads\/2021\/01\/nove-minimalne-invazivni-moznosti-lecby-pooperacni-recidivy-crohnovy-choroby-na-experimentalnim-modelu-foto-2-1600x1200.jpg\" alt=\"Nov\u00e9 minim\u00e1ln\u011b invazivn\u00ed mo\u017enosti l\u00e9\u010dby poopera\u010dn\u00ed recidivy Crohnovy choroby na experiment\u00e1ln\u00edm modelu - foto 2\" class=\"lazyload wp-image-24\" srcset=\"https:\/\/www.ibd-comfort.cz\/content\/uploads\/2021\/01\/nove-minimalne-invazivni-moznosti-lecby-pooperacni-recidivy-crohnovy-choroby-na-experimentalnim-modelu-foto-2-1600x1200.jpg 1600w, https:\/\/www.ibd-comfort.cz\/content\/uploads\/2021\/01\/nove-minimalne-invazivni-moznosti-lecby-pooperacni-recidivy-crohnovy-choroby-na-experimentalnim-modelu-foto-2-500x375.jpg 500w, https:\/\/www.ibd-comfort.cz\/content\/uploads\/2021\/01\/nove-minimalne-invazivni-moznosti-lecby-pooperacni-recidivy-crohnovy-choroby-na-experimentalnim-modelu-foto-2-768x576.jpg 768w, https:\/\/www.ibd-comfort.cz\/content\/uploads\/2021\/01\/nove-minimalne-invazivni-moznosti-lecby-pooperacni-recidivy-crohnovy-choroby-na-experimentalnim-modelu-foto-2-1536x1152.jpg 1536w, https:\/\/www.ibd-comfort.cz\/content\/uploads\/2021\/01\/nove-minimalne-invazivni-moznosti-lecby-pooperacni-recidivy-crohnovy-choroby-na-experimentalnim-modelu-foto-2-2048x1536.jpg 2048w\" sizes=\"auto, (max-width: 1600px) 100vw, 1600px\" \/><\/figure>\n\n\n\n<p>Endoskopick\u00e1 incize sten\u00f3z byla v&nbsp;minulosti ji\u017e prov\u00e1d\u011bna v&nbsp;oblasti j\u00edcnu, \u017ealudku a \u017elu\u010dov\u00fdch cest. V&nbsp;ned\u00e1vn\u00e9 dob\u011b popsal i Nan Lan a Bo Shen \u00fasp\u011b\u0161n\u00e9 proveden\u00ed endoskopick\u00e9 strikturotomie jehlov\u00fdm no\u017eem i u skupiny pacient\u016f s&nbsp;Crohnovou chorobou v&nbsp;oblasti prim\u00e1rn\u00edch i sekund\u00e1rn\u00edch sten\u00f3z. Nen\u00ed v\u0161ak z\u0159ejm\u00e9, zda incize sten\u00f3zy no\u017eem a n\u00e1sledn\u00e9 zaklipov\u00e1n\u00ed spodiny proveden\u00e9ho \u0159ezu (strikturotomie) bude m\u00edt trvalej\u0161\u00ed efekt, ne\u017e proveden\u00ed balonov\u00e9 dilatace. Nen\u00ed rovn\u011b\u017e zn\u00e1m\u00e9, zda tato metoda zvy\u0161uje riziko mo\u017en\u00fdch komplikac\u00ed jako je krv\u00e1cen\u00ed nebo perforace st\u0159eva.<\/p>\n\n\n\n<p>Hodnocen\u00ed p\u0159\u00ednosu nov\u00fdch nezaveden\u00fdch metod l\u00e9\u010dby poopera\u010dn\u00ed recidivy Crohnovy nemoci nen\u00ed mo\u017en\u00e9 v&nbsp;hum\u00e1nn\u00ed medic\u00edn\u011b. Pro tento \u00fa\u010del je nezbytn\u00e9 vytvo\u0159en\u00ed vhodn\u00e9ho experiment\u00e1ln\u00edho modelu na velk\u00e9m laboratorn\u00edm zv\u00ed\u0159eti, kter\u00fd umo\u017e\u0148uje sledov\u00e1n\u00ed a intervence pou\u017eiteln\u00e9 pot\u00e9 v&nbsp;klinick\u00e9 praxi.<\/p>\n\n\n\n<p>C\u00edlem projektu je srovnat na zv\u00ed\u0159ec\u00edm modelu efekt r\u016fzn\u00fdch endoskopick\u00fdch metod (dilatace TTS balonem vs. strikturotomie) v&nbsp;l\u00e9\u010db\u011b anastomotick\u00e9 sten\u00f3zy napodobuj\u00edc\u00ed Crohnovu chorobu. Sekund\u00e1rn\u00edm c\u00edlem, je vytvo\u0159it zv\u00ed\u0159ec\u00ed model simuluj\u00edc\u00ed z\u00e1n\u011btliv\u011b stenotickou anastom\u00f3zu, kter\u00fd by umo\u017e\u0148oval testov\u00e1n\u00ed nov\u00fdch l\u00e9\u010debn\u00fdch technik v\u010detn\u011b hodnocen\u00ed jejich dlouhodob\u00e9ho efektu.<\/p>\n\n\n\n<figure class=\"lazyload block-image alignwide size-large\"><img loading=\"lazy\" decoding=\"async\" width=\"1600\" height=\"1200\" src=\"https:\/\/www.ibd-comfort.cz\/content\/uploads\/2021\/01\/nove-minimalne-invazivni-moznosti-lecby-pooperacni-recidivy-crohnovy-choroby-na-experimentalnim-modelu-foto-1-1600x1200.jpg\" alt=\"Nov\u00e9 minim\u00e1ln\u011b invazivn\u00ed mo\u017enosti l\u00e9\u010dby poopera\u010dn\u00ed recidivy Crohnovy choroby na experiment\u00e1ln\u00edm modelu - foto 1\" class=\"lazyload wp-image-23\" srcset=\"https:\/\/www.ibd-comfort.cz\/content\/uploads\/2021\/01\/nove-minimalne-invazivni-moznosti-lecby-pooperacni-recidivy-crohnovy-choroby-na-experimentalnim-modelu-foto-1-1600x1200.jpg 1600w, https:\/\/www.ibd-comfort.cz\/content\/uploads\/2021\/01\/nove-minimalne-invazivni-moznosti-lecby-pooperacni-recidivy-crohnovy-choroby-na-experimentalnim-modelu-foto-1-500x375.jpg 500w\" sizes=\"auto, (max-width: 1600px) 100vw, 1600px\" \/><\/figure>\n","protected":false},"excerpt":{"rendered":"<p>Idiopatick\u00e9 st\u0159evn\u00ed z\u00e1n\u011bty, Crohnova nemoc a ulcer\u00f3zn\u00ed kolitida, jsou civiliza\u010dn\u00ed, imunitn\u011b podm\u00edn\u011bn\u00e1 onemocn\u011bn\u00ed. Systematick\u00fd p\u0159ehled literatury za posledn\u00edch 60 let potvrzuje rychle rostouc\u00ed incidenci onemocn\u011bn\u00ed zejm\u00e9na v&nbsp;pr\u016fmyslov\u011b vysp\u011bl\u00fdch zem\u00edch, dosahuj\u00edc\u00ed podle posledn\u00edch v\u00fdsledk\u016f 24,3 nov\u011b diagnostikovan\u00fdch pacient\u016f s&nbsp;UC a 12,7&#8230;<\/p>\n","protected":false},"author":1,"featured_media":24,"parent":21,"menu_order":15,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-22","page","type-page","status-publish","has-post-thumbnail","hentry"],"acf":[],"_links":{"self":[{"href":"https:\/\/www.ibd-comfort.cz\/api\/wp\/v2\/pages\/22","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.ibd-comfort.cz\/api\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.ibd-comfort.cz\/api\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.ibd-comfort.cz\/api\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.ibd-comfort.cz\/api\/wp\/v2\/comments?post=22"}],"version-history":[{"count":0,"href":"https:\/\/www.ibd-comfort.cz\/api\/wp\/v2\/pages\/22\/revisions"}],"up":[{"embeddable":true,"href":"https:\/\/www.ibd-comfort.cz\/api\/wp\/v2\/pages\/21"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.ibd-comfort.cz\/api\/wp\/v2\/media\/24"}],"wp:attachment":[{"href":"https:\/\/www.ibd-comfort.cz\/api\/wp\/v2\/media?parent=22"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}