{"id":25,"date":"2021-01-13T21:53:14","date_gmt":"2021-01-13T20:53:14","guid":{"rendered":"https:\/\/www.ibd-comfort.cz\/?page_id=25"},"modified":"2021-01-29T11:29:01","modified_gmt":"2021-01-29T10:29:01","slug":"serove-hladiny-a-protilatky-vedolizumabu","status":"publish","type":"page","link":"https:\/\/www.ibd-comfort.cz\/vyzkum\/serove-hladiny-a-protilatky-vedolizumabu\/","title":{"rendered":"S\u00e9rov\u00e9 hladiny a protil\u00e1tky vedolizumabu"},"content":{"rendered":"\r\n
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S\u00e9rov\u00e9 hladiny vedolizumabu a v\u00fdskyt protil\u00e1tek proti vedolizumabu
u nemocn\u00fdch s idiopatick\u00fdmi st\u0159evn\u00edmi z\u00e1n\u011bty<\/span><\/h1>\r\n \r\n \r\n \r\n \r\n <\/div>\r\n\r\n <\/div>\r\n <\/div>\r\n\r\n \r\n
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\"S\u00e9rov\u00e9<\/a><\/figure><\/div>\n\n\n\n

U nemocn\u00fdch s IBD ji\u017e bylo jasn\u011b prok\u00e1z\u00e1no, \u017ee sledov\u00e1n\u00ed s\u00e9rov\u00fdch koncentrac\u00ed (trough levels) syst\u00e9mov\u00fdch inhibitor\u016f TNFa (infliximabu, adalimumabu) souvis\u00ed s pr\u016fb\u011bhem a v\u00fdvojem onemocn\u011bn\u00ed a s \u00fasp\u011b\u0161nost\u00ed biologick\u00e9 terapie. U nov\u00fdch terapeutick\u00fdch monoklon\u00e1ln\u00edch protil\u00e1tek v\u010detn\u011b vedolizumabu v\u0161ak dosud p\u0159esn\u011b nev\u00edme, o \u010dem n\u00e1s s\u00e9rov\u00e9 hladiny l\u00e9\u010diva informuj\u00ed a jak\u00e9 cut-off (hrani\u010dn\u00ed) hodnoty koncentrac\u00ed vedolizumabu jsou sdru\u017eeny s odpov\u00eddavost\u00ed na l\u00e9\u010dbu. Z\u00e1rove\u0148 je t\u0159eba ov\u011b\u0159it v\u00fdskyt protil\u00e1tek proti vedolizumabu u nemocn\u00fdch s IBD a souvislost jejich v\u00fdskytu s ne\u017e\u00e1douc\u00edmi poinfuzn\u00edmi reakcemi p\u0159ecitliv\u011blosti.<\/p>\n\n\n\n

C\u00edle projektu<\/strong><\/h2>\n\n\n\n

Anal\u00fdza trough levels vedolizumabu a s\u00e9rov\u00fdch hladin protil\u00e1tek proti vedolizumabu v z\u00e1vislosti na Harvey-Bradshawov\u011b indexu\/modifikovan\u00e9m Mayo sk\u00f3re, v\u00fdvoji s\u00e9rov\u00fdch hladin CRP a fek\u00e1ln\u00edch hladin kalprotektinu. Nalezen\u00ed cut-off hodnot hladin l\u00e9\u010diva pro induk\u010dn\u00ed a udr\u017eovac\u00ed f\u00e1zi l\u00e9\u010dby.  Srovn\u00e1n\u00ed nam\u011b\u0159en\u00fdch hodnot s ji\u017e publikovan\u00fdmi sd\u011blen\u00edmi.<\/p>\n\n\n\n

\"S\u00e9rov\u00e9<\/a><\/figure><\/div>\n\n\n\n

Metodika v\u00fdzkumu<\/strong><\/h2>\n\n\n\n

Anal\u00fdza 200 m\u011b\u0159en\u00ed s\u00e9rov\u00fdch hladin VDZ a protil\u00e1tek proti VDZ: 100 m\u011b\u0159en\u00ed z t\u00fddne 6 induk\u010dn\u00ed f\u00e1ze l\u00e9\u010dby a 100 m\u011b\u0159en\u00ed  z t\u00fddne 22 a z pozd\u011bj\u0161\u00edch f\u00e1z\u00ed udr\u017eovac\u00ed l\u00e9\u010dby. Korelace s klinick\u00fdmi a dal\u0161\u00edmi laboratorn\u00edmi parametry. Detekce protil\u00e1tek proti VDZ a anal\u00fdza poinfuzn\u00edch reakc\u00ed.<\/p>\n\n\n\n

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U nemocn\u00fdch s IBD ji\u017e bylo jasn\u011b prok\u00e1z\u00e1no, \u017ee sledov\u00e1n\u00ed s\u00e9rov\u00fdch koncentrac\u00ed (trough levels) syst\u00e9mov\u00fdch inhibitor\u016f TNFa (infliximabu, adalimumabu) souvis\u00ed s pr\u016fb\u011bhem a v\u00fdvojem onemocn\u011bn\u00ed a s \u00fasp\u011b\u0161nost\u00ed biologick\u00e9 terapie. U nov\u00fdch terapeutick\u00fdch monoklon\u00e1ln\u00edch protil\u00e1tek v\u010detn\u011b vedolizumabu v\u0161ak dosud p\u0159esn\u011b nev\u00edme, o \u010dem…<\/p>\n","protected":false},"author":1,"featured_media":26,"parent":21,"menu_order":17,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-25","page","type-page","status-publish","has-post-thumbnail","hentry"],"acf":[],"_links":{"self":[{"href":"https:\/\/www.ibd-comfort.cz\/api\/wp\/v2\/pages\/25","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.ibd-comfort.cz\/api\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.ibd-comfort.cz\/api\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.ibd-comfort.cz\/api\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.ibd-comfort.cz\/api\/wp\/v2\/comments?post=25"}],"version-history":[{"count":0,"href":"https:\/\/www.ibd-comfort.cz\/api\/wp\/v2\/pages\/25\/revisions"}],"up":[{"embeddable":true,"href":"https:\/\/www.ibd-comfort.cz\/api\/wp\/v2\/pages\/21"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.ibd-comfort.cz\/api\/wp\/v2\/media\/26"}],"wp:attachment":[{"href":"https:\/\/www.ibd-comfort.cz\/api\/wp\/v2\/media?parent=25"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}