{"id":36,"date":"2021-01-13T22:05:42","date_gmt":"2021-01-13T21:05:42","guid":{"rendered":"https:\/\/www.ibd-comfort.cz\/?page_id=36"},"modified":"2021-01-28T23:56:47","modified_gmt":"2021-01-28T22:56:47","slug":"deti-a-tehotne","status":"publish","type":"page","link":"https:\/\/www.ibd-comfort.cz\/vyzkum\/deti-a-tehotne\/","title":{"rendered":"D\u011bti a t\u011bhotn\u00e9"},"content":{"rendered":"\r\n
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\r\n DonateforChildren<\/a> \/ Pixabay <\/div>\r\n \r\n
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V\u00fdzkum v oblasti
d\u011bt\u00ed a t\u011bhotn\u00fdch<\/span><\/h1>\r\n \r\n \r\n \r\n \r\n <\/div>\r\n\r\n <\/div>\r\n <\/div>\r\n\r\n \r\n
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Anotace<\/strong><\/h2>\n\n\n\n

Idiopatick\u00e9 st\u0159evn\u00ed z\u00e1n\u011bty (IBD) – Crohnova nemoc a ulcer\u00f3zn\u00ed kolitida \u2013 jsou chronick\u00e1 z\u00e1n\u011btliv\u00e1 onemocn\u011bn\u00ed st\u0159evn\u00edho traktu, kter\u00e1 nejsou medikament\u00f3zn\u011b vyl\u00e9\u010diteln\u00e1. V\u011bt\u0161ina pacient\u016f je diagnostikovan\u00e1 v mlad\u00e9m a reproduk\u010dn\u00edm v\u011bku. Biologick\u00e1 l\u00e9\u010dba (infliximab, adalimumab a golimumab) p\u0159edstavuje v sou\u010dasnosti \u00fa\u010dinnou protiz\u00e1n\u011btlivou l\u00e9\u010dbu IBD. Tato l\u00e9\u010dba se dle posledn\u00edch mezin\u00e1rodn\u00edch a \u010desk\u00fdch doporu\u010den\u00ed pova\u017euje za bezpe\u010dnou i v pr\u016fb\u011bhu t\u011bhotenstv\u00ed. Dosavadn\u00ed studie neprok\u00e1zaly zv\u00fd\u0161en\u00fd v\u00fdskyt ne\u017e\u00e1douc\u00edch \u00fa\u010dink\u016f na v\u00fdvoj plodu nebo n\u00e1r\u016fst komplikac\u00ed v poporodn\u00edm obdob\u00ed. Nicm\u00e9n\u011b \u00fadaje, t\u00fdkaj\u00edc\u00ed se vlivu p\u016fsoben\u00ed t\u011bchto prepar\u00e1t\u016f na dal\u0161\u00ed v\u00fdvoj d\u00edt\u011bte, a p\u0159edev\u0161\u00edm na v\u00fdvoj jeho imunitn\u00edho syst\u00e9mu, jsou zat\u00edm omezen\u00e9. Proto, je pot\u0159eba dlouhodob\u00e9ho systematick\u00e9ho sledov\u00e1n\u00ed t\u011bchto d\u011bt\u00ed k dal\u0161\u00edmu ov\u011b\u0159en\u00ed bezpe\u010dnosti t\u00e9to l\u00e9\u010dby v pr\u016fb\u011bhu t\u011bhotenstv\u00ed. <\/p>\n\n\n\n

C\u00edle projektu<\/strong><\/h2>\n\n\n\n

Jedn\u00e1 se o dlouhodob\u00fd, multicentrick\u00fd projekt. Sledovan\u00e9 d\u011bti jsou vy\u0161et\u0159ovan\u00e9 v pravideln\u00fdch intervalech, kter\u00e9 se v\u011bt\u0161inou shoduj\u00ed s intervaly povinn\u00fdch d\u011btsk\u00fdch l\u00e9ka\u0159sk\u00fdch prohl\u00eddek (m\u011bs\u00edc 12 a 18; rok 3 a pak ka\u017ed\u00fd druh\u00fd rok a\u017e do ukon\u010den\u00ed sledov\u00e1n\u00ed d\u00edt\u011bte u pediatra). Z d\u016fvodu zachov\u00e1n\u00ed jednotn\u00e9ho postupu p\u0159i sledov\u00e1n\u00ed d\u011bt\u00ed, se vy\u0161et\u0159en\u00ed prov\u00e1d\u00ed na specializovan\u00fdch pediatrick\u00fdch pracovi\u0161t\u00edch (Fakultn\u00ed nemocnice Motol, Praha). Sou\u010d\u00e1st\u00ed ka\u017ed\u00e9ho vy\u0161et\u0159en\u00ed je pohovor s d\u011btsk\u00fdm l\u00e9ka\u0159em zam\u011b\u0159en\u00fdm na v\u00fdvoj d\u00edt\u011bte, prod\u011blan\u00e9 infekce, u\u017e\u00edv\u00e1n\u00ed antibiotik a v\u00fdskyt alergi\u00ed. Nav\u00edc p\u0159ed ka\u017edou n\u00e1v\u0161t\u011bvou je rodi\u010d a o\u0161et\u0159uj\u00edc\u00ed pediatr d\u00edt\u011bte po\u017e\u00e1d\u00e1n o vypln\u011bn\u00ed dotazn\u00edku, zam\u011b\u0159en\u00e9ho na zdravotn\u00edho stav d\u00edt\u011bte.<\/p>\n\n\n\n

D\u00e1le je p\u0159i ka\u017ed\u00e9 n\u00e1v\u0161t\u011bv\u011b proveden odb\u011br vzorku krve d\u00edt\u011bte ke stanoven\u00ed specifick\u00fdch imunologick\u00fdch parametr\u016f v\u010detn\u011b alergie a odpov\u011bdi na o\u010dkov\u00e1n\u00ed.<\/p>\n\n\n\n

Dosavadn\u00ed v\u00fdsledky<\/strong> jsou uvedeny v p\u0159ilo\u017een\u00e9 prezentaci<\/a>.<\/p>\n","protected":false},"excerpt":{"rendered":"

Sledov\u00e1n\u00ed d\u011bt\u00ed pacientek s idiopatick\u00fdmi st\u0159evn\u00edmi z\u00e1n\u011bty, kter\u00e9 byly v t\u011bhotenstv\u00ed l\u00e9\u010den\u00e9 biologickou l\u00e9\u010dbou. Anotace Idiopatick\u00e9 st\u0159evn\u00ed z\u00e1n\u011bty (IBD) – Crohnova nemoc a ulcer\u00f3zn\u00ed kolitida \u2013 jsou chronick\u00e1 z\u00e1n\u011btliv\u00e1 onemocn\u011bn\u00ed st\u0159evn\u00edho traktu, kter\u00e1 nejsou medikament\u00f3zn\u011b vyl\u00e9\u010diteln\u00e1. V\u011bt\u0161ina pacient\u016f je diagnostikovan\u00e1 v mlad\u00e9m a…<\/p>\n","protected":false},"author":1,"featured_media":317,"parent":21,"menu_order":13,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-36","page","type-page","status-publish","has-post-thumbnail","hentry"],"acf":[],"_links":{"self":[{"href":"https:\/\/www.ibd-comfort.cz\/api\/wp\/v2\/pages\/36","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.ibd-comfort.cz\/api\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.ibd-comfort.cz\/api\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.ibd-comfort.cz\/api\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.ibd-comfort.cz\/api\/wp\/v2\/comments?post=36"}],"version-history":[{"count":0,"href":"https:\/\/www.ibd-comfort.cz\/api\/wp\/v2\/pages\/36\/revisions"}],"up":[{"embeddable":true,"href":"https:\/\/www.ibd-comfort.cz\/api\/wp\/v2\/pages\/21"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.ibd-comfort.cz\/api\/wp\/v2\/media\/317"}],"wp:attachment":[{"href":"https:\/\/www.ibd-comfort.cz\/api\/wp\/v2\/media?parent=36"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}